Tags: Protein.
CD59 antigen (also called 1F-5Ag H19 HRF20 MACIF MIRL P-18 or protectin) inhibits formation of membrane attack complex (MAC) thus protecting cells from complement-mediated lysis. It has a signaling role as a GPI anchored molecule in T cell activation and appears to have some role in cell adhesion through CD2 (controversial). CD59 associates with C9 inhibiting incorporation into C5b-8 preventing terminal steps in polymerization of the (MAC) in plasma membranes.
