In immunology the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals the complex contains a CD3γ chain a CD3δ chain and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR ζ-chain and CD3 molecules together comprise the TCR complex.
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