The cation channels of sperm also known as Catsper channels or CatSper are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization.
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