Tags: Chemical Compound, Chemical Substance.
Carboxyglutamic acid (or the conjugate base carboxyglutamate) is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found for example in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade Vitamin K is required to introduce gamma-carboxylation of clotting factors II VII IX X and protein Z.
