Tags: Chemical Compound, Chemical Substance.
Carboxycyclophosphamide is an inactive metabolite of the cytotoxic antineoplastic drug cyclophosphamide. In the metabolic pathway of cyclophosphamide inactivation it first metabolizes to 4-hydroxycyclophosphamide then partially tautomerizes into aldophosphamide. Aldophosphamide then in turn is oxidized into carboxycyclophosphamide by the enzyme ALDH (aldehyde dehydrogenase).
