Tags: Drug.

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca Happy tree) a tree native to China used as a cancer treatment in Traditional Chinese Medicine.

Camptothecin.svg
ATC prefix
none
CAS number
7689-03-4
ChEBI
27656
DrugBank
DB04690
FDA UNII code
XT3Z54Z28A
IUPAC name
(S)-4-ethyl-4-hydroxy-1H-pyrano[3'4':67]indolizino[12-b], quinoline-314-(4H12H)-dione
PubChem
2538

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