Tags: Protein.
Calpastatin is a protein that in humans is encoded by the CAST gene.The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4) and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events such as neural vesicle exocytosis and platelet and red-cell aggregation.