Chromosome 9 open reading frame 3 (C9ORF3) also known as aminopeptidase O (APO) is an enyzme which in humans is encoded by the C9ORF3 gene. The protein encoded by this gene is an aminopeptidase which is most closely related in sequence to leukotriene A4 hydrolase (LTA4H). APO is a member of the M1 metalloproteinase family.
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