Tags: Protein.
In molecular biology the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/Grb10/Grb14. It mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase acting as a pseudosubstrate inhibitor. It is composed of two beta strands and a C-terminal helix.
