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Bone resorption is the process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood.The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for the resorption of bone. Osteoclasts are generally present on the outer layer of bone just beneath the periosteum. Attachment of the osteoclast to the osteon begins the process.

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