Tags: Protein.
Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached via an amide bond to a lysine residue in enzymes requiring this coenzyme. Lipoamide acyltransferases have an essential cofactor lipoic acid which is covalently bound via an amide linkage to a lysine group. The lipoic acid cofactor is found in a variety of proteins.