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Bing–Neel syndrome (BNS) is an extremely rare neurologic complication of Waldenström macroglobulinemia (WM). It was first described in 1936 by Jens Bing and Axel Valdemar Neel who observed a case of 2 women 56 and 39 years old presenting with rapid neurodegeneration in the setting of hyperglobulinemia.It involves central nervous system infiltration by neoplastic lymphoplasmacytoid and plasma cells with or without cerebrospinal fluid (CSF) hyperglobulinemia.

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