Tags: Drug.

BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y2. It was one of the first non-peptide Y2-selective antagonists developed and remains among the most widely used tools for studying this receptor. It has been used to demonstrate a role for the Y2 subtype as a presynaptic autoreceptor limiting further neuropeptide Y release as well as modulating dopamine and acetylcholine release.

BIIE-0246_structure.png
CAS number
246146-55-4
IUPAC name
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[([2-(35-dioxo-12-diphenyl-124-triazolidin-4-yl)ethyl]amino)carbonyl]butyl]-1-(2-[4-(611-dihydro-6-oxo-5H-dibenz[be]azepin-11-yl)-1-piperazinyl]-2-oxoethyl)cyclopentaneacetamide
PubChem
9811493

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