Tags: Drug.

Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria Adlumia fungosa Fumariaceae and several Corydalis species. Since it blocks the inhibitory action of GABA receptors the action of bicuculline mimics epilepsy.

Bicuculline.svg
ATC prefix
none
CAS number
485-49-4
ChEBI
3092
FDA UNII code
Y37615DVKC
IUPAC name
(6R)-​6-​[(5S)-​6-​methyl-​5​6​7​8-​tetrahydro​[13]dioxolo​[45-g]​isoquinolin-​5-​yl]​furo[34-e]​[13]​benzodioxol-​8(6H)-​one
PubChem
10237

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