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Bannayan–Riley–Ruvalcaba syndrome (BRRS) is a rare overgrowth syndrome and hamartomatous disorder with occurrence of multiple subcutaneous lipomas macrocephaly and hemangiomas. The disease is inherited in an autosomal dominant form but sporadic cases have been reported.The disease belongs to a family of hamartomatous polyposis syndromes which also includes Peutz–Jeghers syndrome juvenile polyposis and Cowden syndrome.

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