Ascomycin also called Immunomycin FR-900520 FK520 is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases and can help prevent rejection after an organ transplant.Ascomycin acts by binding to immunophilins especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines.
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