Tags: Drug.

Arbaclofen placarbil (ar-BAC-loe-fen pla-KAR-bil also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.

Arbaclofen_placarbil.svg
ATC prefix
none
CAS number
847353-30-4
IUPAC name
(3R)-3-(4-chlorophenyl)-4-[(1S)-2-methyl-1-[(2-methylpropanoyl)oxy]propoxy]carbonyl]amino]butanoic acid
PubChem
11281011

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