Tags: Chemical Compound, Chemical Substance.

Apratoxin A – is a cyanobacterial secondary metabolite known as a potent cytotoxic marine natural product. It is a derivative of the Apratoxin family of cytotoxins. The mixed peptide-polyketide natural product comes from a polyketide synthase/non-ribosomal peptide synthase pathway (PKS/NRPS). This cytotoxin is known for inducing G1-phase cell cycle arrest and apoptosis. This natural product’s activity has made it a popular target for developing anticancer derivatives.

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IUPAC name
(2S3S5S7S10S16S19S22S25E27S)-16-[(2S)-butan-2-yl]-7-tert-butyl-3-hydroxy-22-(4-methoxybenzyl)-2517192025-hexamethyl-8-oxa-29-thia-1417202330-pentaazatricyclo[25.2.1.01014]triaconta-1(30)25-diene-915182124-pentone

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