Amiloride is a potassium-sparing diuretic first approved for use in 1967 (then known as MK 870) used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis but it was revealed inefficient in vivo due to its short time of action therefore longer-acting ENaC inhibitors may prove more effective e.g.
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