AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2 with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor giving it around 180x selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1 explaining the high CB2 selectivity of AM-1221.
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