Tags: Chemical Compound, Chemical Substance.

Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia by Sanofi. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation The target of Flavopiridol is the positive transcription elongation factor P-TEFb. Treatment of cells with Flavopiridol leads to inhibition of P-TEFb and the loss of mRNA production.

Flavopiridol.svg
FDA UNII code
45AD6X575G
IUPAC name
2-(2-chlorophenyl)-57-dihydroxy-8-[(3S4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone

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