Tags: Protein.
Delta-1-pyrroline-5-carboxylate synthetase is an enzyme that in humans is encoded by the ALDH18A1 gene.This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate a critical step in the de novo biosynthesis of proline ornithine and arginine.