Alazocine ((-)-SKF-10047) or (-)-N-allylnormetazocine ((-)-ANMC) was the first drug discovered to act as a σ1 receptor agonist (Ki = 24 nM). It has no significant affinity for the σ2 receptor. Alazocine also acts as a κ-opioid receptor agonist (Ki = 0.4 nM) and to a much lesser extent as an NMDA receptor antagonist (Ki = 587 nM).
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