Tags: Protein.
Anterior gradient protein 2 homolog (AGR-2) also known as secreted cement gland protein XAG-2 homolog is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis. In Xenopus AGR2 plays a role in cement gland differentiation but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response cell migration and cell transformation.