Tags: Enzyme.

ADAM 17 endopeptidase (EC 3.4.24.86 tumor necrosis factor alpha-converting enzyme TACE) is an enzyme. This enzyme catalyses the following chemical reaction Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored cell-surface proteins to shed the extracellular domains This enzyme belongs to the peptidase family M12.

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