Acquired C1 esterase inhibitor deficiency Tags: Disease.Acquired C1 esterase inhibitor deficiency also known as Acquired Angioedema presents with symptoms indistinguishable from hereditary angioedema but generally with onset after the fourth decade of life.C4 levels are low and C3 levels are normal. ICD10 D84.1 (ILDS D84.112) Learn more... Loading...