Tags: Chemical Compound, Chemical Substance.
7-Hydroxymitragynine (mitragynine hydroxyindolenine) is a terpenoid indole alkaloid in the plant Mitragyna speciosa commonly known as Kratom. It has opioid agonistic activity. The potency calculated using pD (2) values was 30-fold higher than that of mitragynine and 17-fold higher than that of morphine respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M.