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4′-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4′-fluorophenyltropane derivative CFT and the 2′-hydroxy analogue salicylmethylecgonine 4′-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake but conversely it is a much stronger serotonin reuptake inhibitor than cocaine resulting in a significantly altered pharmacological profile in animal studies.

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