Tags: Chemical Compound, Chemical Substance.

12-O-Tetradecanoylphorbol-13-acetate (TPA) also commonly known as tetradecanoylphorbol acetate tetradecanoyl phorbol acetate and phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms diacylglycerol.

12-O-Tetradecanoylphorbol-13-acetate.svg
IUPAC name
(1aR1bS4aR7aS7bS8R9R9aS)-9a-(acetyloxy)-4a7b-dihydroxy-3-(hydroxymethyl)-1168-tetramethyl-5-oxo-1a1b44a57a7b899a-decahydro-H-cyclopropa[34]benzo[12-e]azulen-9-yl myristate

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