12-Hydroxyeicosatetraenoic acid Tags: Chemical Compound, Chemical Substance.12-Hydroxyeicosatetraenoic acid (12-HETE) is an eicosanoid. It is a metabolite of arachidonic acid produced by the action of the enzyme arachidonate 12-lipoxygenase. 12-HETE is a highly selective ligand used to label mu opioid receptors. thumbnail IUPAC name (5Z8Z10E12S14Z)-12-Hydroxyicosa-581014-tetraenoic acid Learn more... Loading...