12-Bis(dimethylphosphino)ethane (dmpe) is a diphosphine ligand in coordination chemistry. It can be synthesised by the reaction of methylmagnesium iodide with 12-bis(dichlorophosphino)ethane:Cl2PCH2CH2PCl2 + 4MeMgI → Me2PCH2CH2PMe2 + 4MgICl↑ 1.0 1.1 1.2 ↑