Tags: Enzyme.
11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) is the name of a family of enzymes that catalyze the conversion of inert 11 keto-products (cortisone) to active cortisol or vice versa thus regulating the access of glucocorticoids to the steroid receptors:11β-hydroxysteroid + NADP+ an 11-oxosteroid + NADPH + H+Thus the two substrates of this enzyme are 11beta-hydroxysteroid and NADP+ whereas its 3 products are 11-oxosteroid NADPH and H+.This enzyme belongs to the family of oxidoreductases specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.
