List of articles in "Drug" category - Page 47

PD-217014 is a drug developed by Pfizer and related to gabapentin which similarly binds to the α2δ calcium channels (1 and 2).

CTEP is a research drug developed by Hoffmann-La Roche that acts as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5 binding with nanomolar affinity and over 1000x […]

AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor and was developed for the treatment of obesity. Other cannabinoid antagonists such as rimonabant […]

PF-514273 is a drug developed by Pfizer which acts as an extremely selective antagonist for the CB1 receptor with approximately 10000x selectivity over the closely related CB2 receptor. This very […]

O-2113 is a drug that is a classical cannabinoid derivative which acts as a potent agonist for cannabinoid receptors producing sedation hypothermia and analgesia in animal studies.

O-2050 is a drug that is a classical cannabinoid derivative which acts as a silent antagonist for the CB1 receptor. This gives it an advantage in research over many commonly […]

PF-4800567 is a drug developed by Pfizer which acts as a selective inhibitor of the enzyme Casein kinase 1 epsilon (CK1-ε) and has mainly been used in the study of […]

Retosiban (GSK-221149-A) is an oral drug which acts as a selective sub-nanomolar (Ki = 0.65 nM) oxytocin receptor antagonist with >1400-fold selectivity over the related vasopressin receptors and is being […]

LCZ696 is an investigational combination drug consisting of two antihypertensives (blood pressure lowering drugs) valsartan and AHU-377 in a 1:1 mixture. It is being developed by Novartis. The combination is […]

Salicyluric acid is the glycine conjugate of salicylic acid and is the primary form in which salicylates are excreted from the body via the kidneys. The pathway is very similar […]