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XMEN is a rare genetic disorder of the immune system that illustrates the role of Mg2+ in cell signaling. XMEN stands for “X-linked immunodeficiency with magnesium defect Epstein-Barr virus (EBV) infection and neoplasia.” It is characterized by CD4 lymphopenia severe chronic viral infections and defective T-lymphocyte activation. Investigators in the laboratory of Dr.

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